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practical MIF polymorphisms are associated with autoimmune and rheumatic condition susceptibility and severity.

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Fig. 4: Diagram in the human MIF gene exhibiting its exonic structure and the variant microsatellites in the promoter location.

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The Glide module in Schrödinger was employed for molecular docking calculations [28]. The tautomers and protonation states on the ligands have been produced at pH =7.four by LigPrep in Schrödinger and afterwards docked towards the binding web page of MIF by Glide in additional precision (XP) scoring manner. The bounding box was centered to the cocrystallized ligand.

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